The tetrapod Caerorhachis bairdi Holmes and Carroll from the Lower Carboniferous of Scotland

The tetrapod Caerorhachis bairdi, probably from the Pendleian Limestone Coal Group in the Scottish Midland Valley, is redi agnosed and redescribed, and its affinities are discussed. Caerorachis was originally interpreted as a temnospondyl amphibian, based on characters that are now regarded as primitive for tetrapods, or of uncertain polarity. Several features of Caerorhachis (e.g. gastrocentrous vertebrae, curved trunk ribs, reduced dorsal iliac blade, L-shaped tarsal intermedium) are observed in certain primitive amniotes. In particular, Caerorhachis resembles ‘anthracosaurs’, generally considered to be among the most primitive of stem-group amniotes. The phylogenetic position of Caerorhachis is considered in the light of recently published cladistic analyses of Palaeozoic tetrapods. Most analyses place Caerorhachis at the base of, or within, ‘anthra- cosaurs’. When multiple, equally parsimonious solutions are found, its ‘anthracosaur’ affinities are shown in at least some trees, and are supported by several informative and, generally, highly consistent characters. Alternative phylogenetic placements (e.g. sister taxon to temnospondyls) are usually less well corroborated. If the fundamental evolutionary split of most early tetrapods into stem-group lissamphibians (e.g. temnospondyl s) and stem-group amniotes (e.g. ‘anthracosaurs’) is accepted, then the revised interpretation of Caerorhachi s sheds light on near-ancestral conditions for Amniota

Treatments and placebos for the pathologies of effective field theories

We demonstrate some shortcomings of "fixing the equations," an increasingly popular remedy for time evolution problems of effective field theories (EFTs). We compare the EFTs and their "fixed" versions to the UV theories from which they can be derived in two cases: K-essence and nonlinear Proca theory. We find that when an EFT breaks down due to loss of hyperbolicity, fixing does not approximate the UV theory well if the UV solution does not quickly settle down to vacuum. We argue that this can be related to the EFT approximation itself becoming invalid, which cannot be rectified by fixing.Comment: 5+4 pages. Version published as a PRD lette

The intrinsic pathology of self-interacting vector fields

We show that self-interacting vector field theories exhibit unphysical behaviour even when they are not coupled to any external field. This means any theory featuring such vectors is in danger of being unphysical, an alarming prospect for many proposals in cosmology, gravity, high energy physics and beyond. The problem arises when vector fields with healthy configurations naturally reach a point where time evolution is mathematically ill-defined. We develop tools to easily identify this issue, and provide a simple and unifying framework to investigate it.Comment: 5+4 pages, 3+2 figures. Minor changes to bring into line with published versio

Wearable multimodal skin sensing for the diabetic foot

Ulceration of the diabetic foot is currently difficult to detect reliably in a timely manner causing undue suffering and cost. Current best practice is for daily monitoring by those living with diabetes coupled to scheduled monitoring by the incumbent care provider. Although some metrics have proven useful in the detection or prediction of ulceration, no single metric can currently be relied upon for diagnosis. We have developed a prototype multivariate extensible sensor platform with which we demonstrate the ability to gather acceleration, rotation, galvanic skin response, environmental temperature, humidity, force, skin temperature and bioimpedance signals in real time, for later analysis, utilising low cost Raspberry Pi and Arduino devices. We demonstrate the utility of the Raspberry Pi computer in research which is of particular interest to this issue of electronics - Raspberry Pi edition. We conclude that the hardware presented shows potential as an adaptable research tool capable of gathering synchronous data over multiple sensor modalities. This research tool will be utilised to optimise sensor selection, placement and algorithm development prior to translation into a sock, insole or platform diagnostic device at a later date. The combination of a number of clinically relevant parameters is expected to provide greater understanding of tissue state in the foot but requires further volunteer testing and analysis beyond the scope of this paper which will be reported in due course

The diarrhetic shellfish-poisoning toxin, okadaic acid, provokes gastropathy, dysbiosis and susceptibility to bacterial infection in a non-rodent bioassay, Galleria mellonella

Diarrhetic shellfish-poisoning (DSP) toxins such as okadaic acid and dinophysistoxins harm the human gastrointestinal tract, and therefore, their levels are regulated to an upper limit of 160 μg per kg tissue to protect consumers. Rodents are used routinely for risk assessment and studies concerning mechanisms of toxicity, but there is a general move toward reducing and replacing vertebrates for these bioassays. We have adopted insect larvae of the wax moth Galleria mellonella as a surrogate toxicology model. We treated larvae with environmentally relevant doses of okadaic acid (80–400 μg/kg) via intrahaemocoelic injection or gavage to determine marine toxin-related health decline: (1) whether pre-exposure to a sub-lethal dose of toxin (80 μg/kg) enhances susceptibility to bacterial infection, or (2) alters tissue pathology and bacterial community (microbiome) composition of the midgut. A sub-lethal dose of okadaic acid (80 μg/kg) followed 24 h later by bacterial inoculation (2 × 105 Escherichia coli) reduced larval survival levels to 47%, when compared to toxin (90%) or microbial challenge (73%) alone. Histological analysis of the midgut depicted varying levels of tissue disruption, including nuclear aberrations associated with cell death (karyorrhexis, pyknosis), loss of organ architecture, and gross epithelial displacement into the lumen. Moreover, okadaic acid presence in the midgut coincided with a shift in the resident bacterial population over time in that substantial reductions in diversity (Shannon) and richness (Chao-1) indices were observed at 240 μg toxin per kg. Okadaic acid-induced deterioration of the insect alimentary canal resembles those changes reported for rodent bioassays

Constructing neutron stars with a gravitational Higgs mechanism

In scalar-tensor theories, spontaneous scalarization is a phase transition that can occur in ultradense environments such as neutron stars. The scalar field develops a non-trivial configuration once the stars exceeds a compactness threshold. We recently pointed out that, if the scalar exhibits some additional coupling to matter, it could give rise to significantly different microphysics in these environments. In this work we study, at the non-perturbative level, a toy model in which the photon is given a large mass when spontaneous scalarization occurs. Our results demonstrate clearly the effectiveness of spontaneous scalarization as a Higgs-like mechanism in neutron stars